In dramatic fashion Celta Vigo advanced to the next round in their Europa League campaign, the only Spanish side to do so, and it is quite clear who Eduardo Berizzo's men will be hoping to avoid.
Manchester United and Roma are the two clubs with the most prestigious pedigree, but Olympique Lyon, Ajax and German clubs Schalke 04 and Borussia Monchengladbach won't be easy either.
Jose Mourinho will be hoping to use the Europa League as a way to secure Champions League football for next season, as a race for fourth in the Premier League could be difficult to attain.
Rostov will be the only Russian side as Zenit were knocked out, so no long trips will await the Galician club.
Quite surprisingly, Belgian football is well represented with three teams total, and the competition is more open than ever.