Bayern Munich, Paris Saint-Germain, Juventus, Arsenal and Borussia Dortmund are the big teams to be avoided by the Spanish clubs in the draw for the last 16 of the Champions League, to be held on Monday (12.00 CET) at UEFA's headquarters in Nyon.
Barcelona and Atletico Madrid will be in the bowl containing the champions of each group whilst Real Madrid and Sevilla are in another for those who finished second.
As is traditional, teams from the same country or who have been in the same qualifying group, cannot be paired.
This time, a 'dangerous' draw for the group champions is a possibility as Real, PSG, Manchester City and Bayern Munich, the latter two semi-finalists last season, lie in wait.
The Catalans, who beat Pep Guardiola's side to the Group C summit, have PSG and Bayern as potentially their most difficult opponent but they may also draw Benfica, Porto or Bayer Leverkusen.
Atletico Madrid, runners-up last year, finished top of Group D ahead of Bayern and could be paired with PSG, Benfica, City, Leverkusen or Porto.
Both Atleti and Barcelona will have the theoretical advantage of playing the return leg of the tie at home, something that will elude Los Blancos and Sevilla, the Andalusians back in the knockout stages six years after their last appearance.
Arsenal and Juventus are, on paper, who Zinedine Zidane's side would want to bypass, but the reigning champions might draw either Napoli, Monaco or Leicester City too.
Swap Juve for Borussia Dortmund and then you have the line up from which an opponent will be selected for Jorge Sampaoli's Sevilla.
The first legs will be played on February 14, 15, 21 and 22, with the second legs on March 7, 8, 14 and 15.