Both Spanish giants Barcelona and Real Madrid will face a lower league sides from Segunda B in the last 32 of the Copa del Rey after the draw was made on Friday morning.
The Spanish heavyweights will take on Melilla and Cultural Leonesa respectively while Atletico Madrid play Sant Andreu, the only third tier side remaining in the competition.
The first legs will take place between October 30 and November 1 with the return fixtures between December 4 and 6.
There will be four all-LaLiga Santander clashes: Athletic Club vs Huesca, Alaves vs Girona, Leganes vs Rayo Vallecano and Celta Vigo vs Real Sociedad.
Copa del Rey full fixtures
Melilla vs Real Madrid
Sant Andreu vs Atlético de Madrid
Ebro vs Valencia
Cultural Leonesa vs Barcelona
Villanovense vs Sevilla
Racing de Santader vs Betis
Almería vs Villarreal
Mallorca vs Valladolid
Cádiz vs Espanyol
Sporting vs Eibar
Lugo vs Levante
Córdoba vs Getafe
Athletic vs Huesca
Alavés vs Girona
Leganés vs Rayo
Celta vs Real Sociedad
Spanish La liga predictions