Roma fell just short of a comeback as Lyon knocked them out in the Europa League last 16. The second-placed Serie A side trailed 5-2 on aggregate when Mouctar Diakhaby headed the French side into the lead on the night. But Kevin Strootman prodded home an immediate equaliser and a Lucas Tousart own goal narrowed the gap but Roma could not find a late strike to take them through on away goals. Edin Dzeko fired a late chance over. Schalke came from 2-0 down, and 3-1 on aggregate, to beat Bundesliga rivals Borussia Monchengladbach on away goals. Andreas Christensen and Mahmoud Dahoud had put Gladbach in control before Leon Goretzka's strike and Nabil Bentaleb's penalty. Ryan Babel scored his first two European goals since 2010 as 10-man Besiktas beat Olympiakos 4-1 in Istanbul, 5-2 on aggregate.

Celta Vigo, Spain's only representatives left in the tournament, beat FK Krasnodar 2-0 in Russia to progress 4-1 overall. Bertrand Traore and Kasper Dolberg scored as Ajax beat FC Copenhagen 2-0 to overturn a 2-1 first-leg deficit to progress. Anderlecht beat Apoel Nicosia 1-0 (2-0 on aggregate), while Genk beat fellow Belgians Gent 6-3 on aggregate after a 1-1 second-leg draw. Manchester United beat FC Rostov 1-0 to go through 2-1 overall.