It had been expected that Rooney, 31, was going to be involved because he did not go to Russia for the Europa League last-16 meeting with FC Rostov on Thursday. Rooney was expected to be named in Gareth Southgate's England squad on Thursday for the friendly against Germany on 22 March and World Cup qualifier against Lithuania at Wembley on 26 March. He became United's record goalscorer in January, eclipsing Sir Bobby Charlton, but has played only once since 1 February and last month turned down offers to move to China in order to complete the season at Old Trafford.
Chelsea head coach Antonio Conte said: "In October, before the game [won 4-0 by Chelsea], I was sure of facing a great team. It's the same now. Manchester United have, together with [Manchester] City, the best squad in the league. "We have a good identity. We are showing good football, but for sure it will be a really tough game against a good team. "I hope to be favourites, but to show this on the pitch, not only in the words. The facts are on the pitch. We must talk during the game on the pitch, not before. I prefer to focus on the game, and my players to speak with facts."
Manchester United manager Jose Mourinho said: "We cannot go with Nicky Butt's team [ie players from the under-23 team, managed by Butt]. Manchester United is too big. Manchester United is the winner of the competition. "It is not Chelsea's fault that we were given this Monday match, so we have to make changes for sure... but we cannot go to Stamford Bridge with a Nicky Butt team."