Luis Enrique had already picked his starting XI for Barcelona's trip to Granada with four key players absent, and yet matters only got worse 15 minutes in when Rafinha pulled up injured.
A muscle complaint did for the Spaniard who had only just returned from a knee problem, which in turn was responsible for ending a prominent spell in the side's 3-4-3 system.
Paco Alcacer replaced Rafinha on the Estadio Nuevo Los Carmenes pitch, taking up a right wing position as the coach stuck to the 4-3-3 he'd initially set up with.
After the game, Barcelona announced that Rafinha had injured the meniscus ligament of his right knee, with tests to be carried out in the coming days to determine the length of his absence.
The Brazilian suffered a similar injury in 2015, keeping him out for around six months.
