Following his substitution at Valencia on Wednesday night, it has been confirmed that Real Madrid's Raphael Varane has suffered a Grade 2 muscle injury in the femoral biceps of the left leg, and he will miss a number of matches as a result.
The critical Champions League return against Napoli is one where Zinedine Zidane will now have to shuffle his defensive pack, along with the LaLiga games against Las Palmas, Eibar and Real Betis.
Real noted on their official website that the downtime for this type of injury is a minimum of three weeks, almost certainly four.